Experimental Models

View Edit Model Name Center Base Model Organ Device Type Versions Description
View 2D on 96 Well Plate Disease Biophysics Group Heart 96 Well Plate Static-2D 0
View Arterial Pump Vanderbilt Institute for Integrative Biosystems Research and Education Arterial Pump Heart Circulation Pump Fluidic-3D 0
View Atrial-MEA Texas A&M Tissue Chip Validation Center Heart Atrial MEA Static-2D 1 Single chamber model of atrial monolayer. MEA allows for measurement of electrical activity on an 8x8 array.
View Calcium conduction of iPSC derived cardiomyocyte tissues Wyss Institute-Kit Parker Lab FIG substrate Heart Fiber infused gel substrate Static-2D 0
View Cardiac MPS UC Berkeley Healy Lab Heart/Cardiac (Healy) Heart Cardiac MPS Scaffold Fluidic-3D 2 MPS with microcirculation mimicking the in vivo transport, which includes continuous exchange of nutrients, constant exposure of the tissue to fresh drug compounds, and removal of metabolic waste products.
View Cardiac Static [MIT 96w] Translational Center of Tissue Chip Technologies Heart/Cardiac (Healy) Heart 96 Well Plate Static-2D 0 The MIT TC2T static plate companion to UC Berkeley's Cardiac MPS
View Cardiac Static [TAMU 384w] Texas A&M Tissue Chip Validation Center Heart/Cardiac (Healy) Heart Corning 384 well microplate, low flange Static-2D 0 384-well companion model for Heart MPS developed and used at Texas A&M
View Cardiac Static [TAMU 96w] Texas A&M Tissue Chip Validation Center Heart/Cardiac (Healy) Heart 96 Well Plate Static-2D 0 Texas A&M static, 2D co-model for the Cardiac MPS. Cells are plated into a 96-well plate.
View Human Engineered Cardiobundles Duke University Truskey Lab Heart 12-Well Plate Static-3D 0
View Human Engineered CPVT Myocardium Disease Biophysics Group Heart Muscular Thin Film (MTF) Static-3D 0
View iPSC derived cardiomyocyte tissues Disease Biophysics Group Heart Fiber infused gel substrate Static-2D 0
View microHeart Javelin Biotech Heart 96-half-well plate (micro-patterned) Static-2D 0 iPSC-derived cardiomyocytes plated on a micropatterned 96-half-well plate. Micropatterning aligns cells similarly to structure of heart muscle in-vivo.
View Muscle activation in geometrically insulated cardiac tissues node Wyss Institute-Kit Parker Lab Heart Cardiac tissue chip Static-2D 0 In cardiomyocytes, pacemaking arises from an interplay between hyperpolarizing and dominating depolarizing currents during the phase 4 depolarization period (the period between repolarization and the rising phase of the subsequent action potential). In the sinoatrial node, the hyperpolarization-induced inward current (HCN isoforms) of cardiac pacemaker cells plays a major role in pacemaking (47). However, in the case of our G-node where stem cell-derived CMs and NRVMs supposedly lack the expression of HCNs, the pacemaking potentials are a result of inward currents produced by Ca2+ cycling (driven by rhythmic releases of intracellular Ca2+ from the sarco/endoplasmic reticulum). The remaining question was how a region of cells initiate coordinated pacemaking and how this relates to electrical cell-to-cell coupling. The geometrical node design plays a crucial role here because the current being exchanged between individual cells of different membrane potentials is locally accumulated in the membrane capacitance at the edges and is reflected at the tissue edges. The reflection of intracellular currents at the tissue edges synchronizes the spontaneous activity in the structurally isolated small tissues like a G-node and increases their firing rate. The mechanism of reflection at the corners of cultures behave similarly (since downstream impedance is reduced), in particular the anterior corners with acute angles albeit less than in the G-node, and as a result, firing is enhanced in the whole anterior side.
View Muscular Thin Film (MTF) Wyss Institute-Kit Parker Lab Heart Muscular Thin Film Static-3D 0
View Tissue Engineered Ventricle Disease Biophysics Group Heart Tissue Engineered Ventricle Static-3D 0