This system includes two bone marrow lines, Kasumi-1 myeloblasts and MEG-01 megakaryocytes, along with primary human hepatocytes to measure the effects of drugs on bone marrow proliferation and on liver with organ-organ interactions between the liver and bone marrow.
Flow within the system is created by a rocking platform with a defined action of 1 oscillation per minute at an amplitude of 1 degree. This creates a recirculating flow between the system's various chambers.
McAleer et al. Sci Transl Med 2019
This system contains both an MDR+ vulva carcinoma–derived cell line (SW-962) and an MDR− breast cancer cell line (MCF-7), a liver compartment, and two separate bioMEMS devices to measure cardiac electrical and mechanical function.
Cardiac mechanical function is evaluated by incorporating the cardiomyocytes onto custom arrays of microscale cantilevers and calculating force and frequency dynamics from laser-based measurements of cantilever bending resulting from cardiomyocyte contractions.
Cardiac electrical function was measured via a MEA amplifier system by incorporating and chemically patterning cardiomyocytes onto cMEAs to produce a defined conduction path along a series of surface-embedded microelectrodes. Electrically stimulated cardiomyocyte activity was generated inside the system with housing-embedded electrodes for cantilevers and via stimulation through the MEA chip for electrical measurements.
Flow within the system is created by a rocking platform with a defined action of 1 oscillation per minute at an amplitude of 1 degree. This creates a recirculating flow between the system's various chambers.
McAleer et al. Sci Transl Med 2019
A catch-all model to describe treatments applied to an entire cell culture flask.
The cell line cultured in this model will change on a study-by-study basis, as this a generic model used to facilitate data entry of toxicity data.
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