MatTek’s EpiAirway System consists of normal, human-derived tracheal/bronchial epithelial cells (TBE) which have been cultured to form a multilayered, highly differentiated model which closely resembles the epithelial tissue of the respiratory tract. Histological cross-sections of both the in-vitro tissue and a normal human bronchiole reveal a pseudostratified epithelial structure.
Transmission electron microscopy shows numerous microvilli and cilia on the apical surface of the cultures and confirm the presence of tight junctions. Transepithelial electrical resistance of the tissue is similar to in vivo tissue. Mucins are secreted at the apical surface.
The EpiAirway cultures are grown on cell culture inserts at the air-liquid interface, allowing for gas phase exposure of volatile materials for airway inflammation and irritant studies. This convenient format also allows the facile measurement of transepithelial permeability for inhaled drug delivery studies. The tissues can also be used to investigate mechanisms of bacterial infection of the respiratory tract. These and other studies involving asthma, cytokine responses, or various airway disorders can be performed using the EpiAirway tissue.
This is the same base chip as the earlier small airway model, however the top layer has been altered to allow for airflow directly over the cells seeded at ALI (See picture)
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