This model is based on the Mimetas 3-lane organoplate. It contains podocytes and glomerular endothelial cells layered in the "glomerular" channel, as well as an empty, "vascular" channel on the other side of the gel. The gel lane is filled with collagen ECM.
A "2D," 96-well plate based model of Himmelfarb et al.'s Kidney Proximal Tubule organ model. This model simply seeds the RPTEC directly into the wells of the plate. There is no flow.
The kidney tubule MPS exhibits long-term viability, retains polarized expression and function of proteins essential for reabsorptive and secretory transport, responds to physiological stimuli, and performs critical biochemical synthetic activities.
PTECs grown in the MPS polarize with proteins selectively localized to the basolateral and apical aspects of the tubular epithelium and exhibit expected morphological and functional phenotypes of proximal tubule epithelium in vivo out to 28+ days.
MIT's modification of the Kidney Proximal Tubule model to work in the triple channel Nortis Har-v1 (TSC-xxx) device instead of the original Nortis Par (SCC-xxx) device.
An initial version of the KPT MPS model, based on Nortis' prototype Par-V1 device. This model was used in the Weber et al. 2016
The kidney tubule MPS exhibits long-term viability, retains polarized expression and function of proteins essential for reabsorptive and secretory transport, responds to physiological stimuli, and performs critical biochemical synthetic activities.
PTECs grown in the MPS polarize with proteins selectively localized to the basolateral and apical aspects of the tubular epithelium and exhibit expected morphological and functional phenotypes of proximal tubule epithelium in vivo out to 28+ days.
This model uses the CNBio T12 plate with Transwells (0.4uM). Proximal tubule cells are seeded either in monoculture, or co-culture with endothelial cells, and exposed to flow within the system.
This chip is based on the Mimetas 3-Lane Organoplate. RPTECs are seeded in the "tubular" channel, and HUVECs in the "vascular" channel. 4mg/mL Collagen I gel separates the 2 fluidic layers.
This model represents the RED assay conditions and protocol used when testing serum compound binding for the media used in the Kidney Proximal Tubule model.Serum protein concentration is low, at 0.5%.
Two channel kidney epithelial model with a porous polyester membrane
Loading...
This site requires cookies to function properly. Cookies are also used for basic analytics to better serve users. Data are collected anonymously, and not sold or otherwise distributed by the proprietors of this site. By using this site, you consent to the cookies necessary for its basic function. If you would like to customize cookies click here.
Essential cookies are defined as those that are necessary for a website to function correctly, such as maintaining a user's session and supporting the secure transmission of data.
Non-essential cookies in the case of the BioSystics-AP are currently limited to the integration of Google Analytics for the purposes of improving the platform. Examples of the information captured include the user's country of origin, the pages they visit, and the type of device/browser used to do so.