Experimental Models

View Edit Model Name Center Base Model Organ Device Type Versions Description
View Tissue Engineered Blood Vessel - 2 Layer Duke University Truskey Lab TEBV Vasculature TEBV Chamber Fluidic-3D 1 The molds used in this work were created using acrylic and composed of 5 parts, which form the fabrication mold and prefusion chamber (Fig. S1). The TEBV (2 layers) fabrication mold is formed from parts A, B, and C. Part A housed the mandrels about which TEBVs were made and is used in both the fabrication mold and prefusion chamber. There are four steel hollow mandrels (outer diameter 0.63 mm, inner diameter 0.33 mm) at opposite sides of part A, which are mirror reflections of each other and link the assembled chamber to the perfusion tubing and pump. In the fabrication step, the halves of each mandrel are inserted into the chamber (Part A) and brought into contact with each other (Fig. S1ai and S1bi). Part B forms the top layer of the seeding mold with inlets/outlets and grooves, and part C is the bottom layer of the seeding mold with grooves (Suppl Fig. S1aii and S1bii). The grooves on the top and bottom layers each form four semicircular channels (diameter 2.2 mm, length 24 mm) to be used as molds. Once the high-density collagen containing the hNDFs is added and gelled, parts B and C are removed, and the collagen TEBVs are dehydrated. Then the mandrels are drawn out forming a lumen. Following fixation of the collagen tubing on the mandrels, two new flat covers are added (parts D and E) and the final perfusion chamber is completed. The steel mandrels are used for perfusion, with one side acting as the media inlet, and the other as the outlet.
View Vascularized Tumor Model UC Irvine Christopher Hughes Lab Vasculature / Vascularized Tumor Vasculature UCIVTM Fluidic-3D 7 This “tumor-on-a-chip” platform incorporates human tumor and stromal cells that grow in a 3D extracellular matrix and that depend for survival on nutrient delivery through living, perfused microvessels.
View Vascularized Tumor Monoculture [96w] UC Irvine Christopher Hughes Lab Vasculature / Vascularized Tumor Vasculature 96 Well Plate Static-2D 3 A monoculture of various cancer cell lines used to provide companion growth data for cancer cell lines that are used in the parent, 3D Vascularized Tumor Model.
View Vascularized Tumor [TAMU 96w] Texas A&M Tissue Chip Validation Center Vasculature / Vascularized Tumor Vasculature 96 Well Flat Clear Bottom Black Polystyrene TC-Treated Static-2D 4 A 2D "companion model" in a 96-well plate made by TAMU
View Venous Reservoir University of Pittsburgh Drug Discovery Institute Venous Reservoir Vasculature Reservoir Fluidic-3D 0
View Vessel adventia Zhang Lab (BWH & HMS) Vasculature Whole thermoplastic chip-1 Fluidic-3D 2