The Mattek Epi-Intestinal model is based on human small intestinal cells (ileum) differentiated after being seeded onto permeable supports under air-liquid interface culture conditions. This commercial model has been well characterized and is available in different formats, including a “full thickness” model in which gut cells are grown on top of a smooth muscle epithelial layer, or a “partial thickness” model with just the gut epithelial cells.
Gut epithelial monolayers grown on 6.5 mm Transwell inserts
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