Experimental Models

View Edit Model Name Center Base Model Organ Device Type Versions Description
View Bone Columbia University Laboratory for Stem Cells and Tissue Engineering Bone (Columbia) Bone HeLiVaSkCa Bone Cancer Module Static-3D 2 Bone was grown from adult hMSC capable of osteogenic differentiation within native bone ECM serving as a structural scaffold. An in-vitro model of Ewing’s sarcoma that mimics the key properties of the native tumor and provides the tissue context and physical regulatory signals.
View Bone [TAMU Static] Texas A&M Tissue Chip Validation Center Bone (Columbia) Bone 96 Well Flat Clear Bottom Black Polystyrene TC-Treated Static-2D 0 A 2D comparison model for Columbia's Bone/Bone-Tumor MPS model. Seeded with 10,000 cells per well.
View Bone Tumor Spheroids [MIT] Translational Center of Tissue Chip Technologies Bone (Columbia) Bone Falcon 15mL Conical Centrifuge Tube Fluidic-3D 0 Tumor spheroids formed from ATCC's RD-ES cell-line (transfected with GFP by Colombia Univeristy).Stored in standard 15 mL conical tube.
View Osteochondral Bioreactor System Four in Series University of Pittsburgh Center for Cellular and Molecular Engineering Joint (Lin) Bone Fabricated Osteochondral Construct 4 in Series Fluidic-3D 1 Four multi-layer devices in series. More information to be added later.
View Osteochondral Bioreactor System in 24 Well Plate University of Pittsburgh Center for Cellular and Molecular Engineering Joint (Lin) Bone 24 Well Fabricated Osteochondral Construct Fluidic-3D 1 The 3D structures of the bioreactor were modeled using Magics 14 (Materialise, Belgium). The chamber and insert were fabricated using a stereolithography apparatus (EnvisionTec, Germany) employing e-shell 300 as the resin. A multichamber bioreactor was fabricated and fitted into a microfluidic base. An individual bioreactor is composed of a removable insert within a chamber of a well on a 24-well microfluidic plate. The chamber is fixed in place with two O-rings. The osteochondral construct within the insert creates the separation between the upper (chondrogenic) and lower (osteogenic) medium conduits. Opposing gradients of chondrogenic and osteogenic factors and stimulants aid in forming an interface. A single bioreactor is formed by the inset and lid in a well of the plate. Chondrogenic medium (CM) are supplied through upper conduit and osteogenic medium (OM) through the lower conduit.
View RED - Bone Texas A&M Tissue Chip Validation Center Bone (Columbia) Bone Single-Use RED Plate for 48 Samples Static-2D 0 This model represents the RED assay conditions and protocol used when testing serum compound binding for the media used in Columbia's Bone/Bone-Tumor model.Serum protein concentration is at ??%.