Experimental Models

View Edit Model Name Center Base Model Organ Device Type Versions Description
View 0.45 um porous PET transwell vLAMPS model University of Pittsburgh Drug Discovery Institute Liver 0.45um porous PET transwell 6.5mm 24 well plate Static-3D 0 Static Transwells (PET, 0.45 µm pore size) vLAMPS (vascularized Human Liver Acinus Microphysiological System).
View 2D Cell Culture - Kidney Texas A&M Tissue Chip Validation Center Kidney 96 well Plate Static-2D 1
View 2D- liver-PHH-7 Day-high FFA-treatment University of Pittsburgh Drug Discovery Institute Liver 96 Well Flat Clear Bottom Black Polystyrene TC-Treated Static-2D 0
View 2D Mono-layer Hepatocytes University of Pittsburgh Drug Discovery Institute Liver 96 Well Flat Clear Bottom Black Polystyrene TC-Treated Static-2D 0 This is a hepatocytes mono-layer culture.
View 2D on 96 Well Plate Disease Biophysics Group Heart 96 Well Plate Static-2D 0
View 2D Studies on 24-well plate Duke University Truskey Lab Skeletal Muscle 24 Well Plate Static-2D 0
View 3D Bioprinted Breast Cancer Model (Princeton University-Boston University) Translational Center of Tissue Chip Technologies 3D-BCM-PB Breast Generic Slide Static-3D 1 Type I collagen self-assembles into three-dimensional (3D) fibrous networks. These dynamic viscoelasticmaterials can be remodeled in response to mechanical and chemical signals to form anisotropicnetworks, the structure of which influences tissue development, homeostasis, and disease progression.Conventional approaches for fabricating anisotropic networks of type I collagen are often limitedto unidirectional fiber alignment over small areas. Here, we describe a new approach for engineeringcell-laden networks of aligned type I collagen fibers using 3D microextrusion printing of a collagenMatrigel ink. We demonstrate hierarchical control of 3D-printed collagen with the ability to spatiallypattern collagen fiber alignment and geometry. Our data suggest that collagen alignment results froma combination of molecular crowding in the ink and shear and extensional flows present during 3Dprinting. We demonstrate that human breast cancer cells cultured on 3D-printed collagen constructsorient along the direction of collagen fiber alignment. We also demonstrate the ability to simultaneouslybioprint epithelial cell clusters and control the alignment and geometry of collagen fibers surroundingcells in the bioink. The resulting cell-laden constructs consist of epithelial cell clusters fully embeddedin aligned networks of collagen fibers. Such 3D-printed constructs can be used for studies ofdevelopmental biology, tissue engineering, and regenerative medicine.
View 48 well plate Hukriede Lab Kidney Organoid University of Pittsburgh Hukriede Lab Kidney 48 Well Plate Static-3D 0
View Arterial Pump Vanderbilt Institute for Integrative Biosystems Research and Education Arterial Pump Heart Circulation Pump Fluidic-3D 0
View Atrial-MEA Texas A&M Tissue Chip Validation Center Heart Atrial MEA Static-2D 1 Single chamber model of atrial monolayer. MEA allows for measurement of electrical activity on an 8x8 array.
View BBB-iPS-BMEC and brain cells-TW24 Texas A&M Tissue Chip Validation Center Brain 24 Well Transwell Static-2D 1
View BBB-iPS-BMEC and brain cells-TW24 fluidic Texas A&M Tissue Chip Validation Center Brain 24 Well Transwell Fluidic-2D 1 0, 0.5, 1, 1.5, 2, 2.5 ul/sec flow rates in CNBIO devices
View BBB-iPS-BMEC and brain cells-TW96 Texas A&M Tissue Chip Validation Center BBB-IPS 1cell-24well Brain Corning 96 well Transwell Static-2D 1 0.143 cm2 Corning collagen IV and fibronectin pre-coated 96 well transwel plate
View BBB-iPS-BMEC monolayer TC96 Texas A&M Tissue Chip Validation Center Brain 96 Well Flat Clear Bottom Black Polystyrene TC-Treated Static-2D 1 6.5-mm Corning collagen IV and fibronectin pre-coated 96 well cell culture plate
View BBB-iPS-BMEC monolayer TW24 Texas A&M Tissue Chip Validation Center Brain 24 Well Transwell Static-2D 1
View BBB-iPS-BMEC-TW24 fluidic Texas A&M Tissue Chip Validation Center Brain 24 Well Transwell Fluidic-2D 1
View BBB-iPS-BMEC-TW96 Texas A&M Tissue Chip Validation Center Brain Corning 96 well Transwell Static-2D 1
View Blood-Brain Barrier (NVU) Vanderbilt Institute for Integrative Biosystems Research and Education NVU / BBB (Vandy) Brain Neurovascular Unit Fluidic-3D 1 Two chambered model of the blood-brain barrier.
View BoaC Bone Marrow/Liver Hesperos Multiple Body on a Chip Microfluidic Fluidic-2D 1 This system includes two bone marrow lines, Kasumi-1 myeloblasts and MEG-01 megakaryocytes, along with primary human hepatocytes to measure the effects of drugs on bone marrow proliferation and on liver with organ-organ interactions between the liver and bone marrow. Flow within the system is created by a rocking platform with a defined action of 1 oscillation per minute at an amplitude of 1 degree. This creates a recirculating flow between the system's various chambers. McAleer et al. Sci Transl Med 2019
View BoaC MDR Cancer Hesperos Multiple Body on a Chip Microfluidic Static-2D 2 This system contains both an MDR+ vulva carcinoma–derived cell line (SW-962) and an MDR− breast cancer cell line (MCF-7), a liver compartment, and two separate bioMEMS devices to measure cardiac electrical and mechanical function. Cardiac mechanical function is evaluated by incorporating the cardiomyocytes onto custom arrays of microscale cantilevers and calculating force and frequency dynamics from laser-based measurements of cantilever bending resulting from cardiomyocyte contractions. Cardiac electrical function was measured via a MEA amplifier system by incorporating and chemically patterning cardiomyocytes onto cMEAs to produce a defined conduction path along a series of surface-embedded microelectrodes. Electrically stimulated cardiomyocyte activity was generated inside the system with housing-embedded electrodes for cantilevers and via stimulation through the MEA chip for electrical measurements. Flow within the system is created by a rocking platform with a defined action of 1 oscillation per minute at an amplitude of 1 degree. This creates a recirculating flow between the system's various chambers. McAleer et al. Sci Transl Med 2019
View Bone Columbia University Laboratory for Stem Cells and Tissue Engineering Bone (Columbia) Bone HeLiVaSkCa Bone Cancer Module Static-3D 2 Bone was grown from adult hMSC capable of osteogenic differentiation within native bone ECM serving as a structural scaffold. An in-vitro model of Ewing’s sarcoma that mimics the key properties of the native tumor and provides the tissue context and physical regulatory signals.
View Bone [TAMU Static] Texas A&M Tissue Chip Validation Center Bone (Columbia) Bone 96 Well Flat Clear Bottom Black Polystyrene TC-Treated Static-2D 0 A 2D comparison model for Columbia's Bone/Bone-Tumor MPS model. Seeded with 10,000 cells per well.
View Bone Tumor Spheroids [MIT] Translational Center of Tissue Chip Technologies Bone (Columbia) Bone Falcon 15mL Conical Centrifuge Tube Fluidic-3D 0 Tumor spheroids formed from ATCC's RD-ES cell-line (transfected with GFP by Colombia Univeristy).Stored in standard 15 mL conical tube.
View bpLAMPS University of Pittsburgh Drug Discovery Institute Liver 24 Well Transwell Static-3D 3 Transwell bioprinted LAMPS model
View Brain University of Wisconsin-Madison-Thomson Lab Brain (Thomson) Brain Costar 24-well Transwell Static-3D 1 A reproducible 3D neural constructs that incorporates vascular and microglial components derived by culturing precursor cells from the H1 human ES cell line on synthetic hydrogels under defined conditions. Components include di
View Brain [MIT Cell Free] Javelin Biotech Brain (Thomson) Brain Costar 24-well Transwell Static-3D 0 A cell free version of the Thompson Brain MPS model used by MIT to investigate compound binding.
View Brain MPS [MIT 96w Static] Translational Center of Tissue Chip Technologies Brain MPS [MIT 96w Static] Brain 96 Well Plate Clear Flat Bottom Static-2D 0 MIT's companion 96-well static model for the UWM Brain MPS.
View Brain Spheroids Johns Hopkins Thomas Hartung Brain Spheroids (Hartung) Brain 6 Well Plate [Generic] Fluidic-3D 1 A reproducible iPSC-derived human 3D brain microphysiological system (BMPS), comprised of differentiated mature neurons and glial cells (astrocytes and oligodendrocytes) that reproduce neuronal-glial interactions and connectivity. BMPS mature over eight weeks and show the critical elements of neuronal function: synaptogenesis and neuron-to-neuron (e.g., spontaneous electric field potentials) and neuronal-glial interactions (e.g., myelination), which mimic the microenvironment of the central nervous system, rarely seen in vitro before.
View Brain Spheroids [24-well] Johns Hopkins Thomas Hartung Brain Spheroids (Hartung) Brain 24 Well Plate Static-2D 0 Spheroids were assayed in 24-well plate. A reproducible iPSC-derived human 3D brain microphysiological system, comprised of differentiated mature neurons and glial cells (astrocytes and oligodendrocytes) that reproduce neuronal-glial interactions and connectivity. BMPS mature over eight weeks and show the critical elements of neuronal function: synaptogenesis and neuron-to-neuron (e.g., spontaneous electric field potentials) and neuronal-glial interactions (e.g., myelination), which mimic the microenvironment of the central nervous system, rarely seen in vitro before.
View Calcium conduction of iPSC derived cardiomyocyte tissues Wyss Institute-Kit Parker Lab FIG substrate Heart Fiber infused gel substrate Static-2D 0
View Cardiac MPS UC Berkeley Healy Lab Heart/Cardiac (Healy) Heart Cardiac MPS Scaffold Fluidic-3D 2 MPS with microcirculation mimicking the in vivo transport, which includes continuous exchange of nutrients, constant exposure of the tissue to fresh drug compounds, and removal of metabolic waste products.
View Cardiac Static [MIT 96w] Translational Center of Tissue Chip Technologies Heart/Cardiac (Healy) Heart 96 Well Plate Static-2D 0 The MIT TC2T static plate companion to UC Berkeley's Cardiac MPS
View Cardiac Static [TAMU 384w] Texas A&M Tissue Chip Validation Center Heart/Cardiac (Healy) Heart Corning 384 well microplate, low flange Static-2D 0 384-well companion model for Heart MPS developed and used at Texas A&M
View Cardiac Static [TAMU 96w] Texas A&M Tissue Chip Validation Center Heart/Cardiac (Healy) Heart 96 Well Plate Static-2D 0 Texas A&M static, 2D co-model for the Cardiac MPS. Cells are plated into a 96-well plate.
View Cell Circuit University of Pittsburgh Drug Discovery Institute Multiple Organs 8 Circuit Plate Fluidic-3D 1 Single cell model in the 8 circuit format
View ChipShop PolySytrene University of Pittsburgh Drug Discovery Institute Liver ChipShop Fluidic 557 Fluidic-3D 1 ChipShop 557 device constructed from polystyrene
View ChipShop reactor chamber chip microfluidic 557 University of Pittsburgh Drug Discovery Institute Liver ChipShop Fluidic 557 Fluidic-3D 2 4 cell liver model based on LAMPS
View ChipShop Zeonar University of Pittsburgh Drug Discovery Institute Liver ChipShop Fluidic 557 Static-3D 1 ChipShop model 557 constructed from O2 permeable zeonar (cyclo Olefin Polymer)
View CNBio Liver Javelin Biotech Liver LC-CP Fluidic-3D 1 The CN Bio LiverChip is a 3D liver tissue model which is continuously perfused for long-term culture. A scaffold allows formation of 3D tissue structures from primary human hepatocytes, through which culture medium is circulated repeatedly via an onboard pneumatic microfluidic pumping system.
View CnBio LiverChip Translational Center of Tissue Chip Technologies Liver LC-CP Fluidic-3D 1 The CN Bio LiverChip is a 3D liver tissue model which is continuously perfused for long-term culture. A scaffold allows formation of 3D tissue structures from primary human hepatocytes, through which culture medium is circulated repeatedly via an onboard pneumatic microfluidic pumping system.
View CNBIO Liver-MPS (LC12) Consumable Plate CNBio Liver Liver-MPS (LC12) Consumable Plate Fluidic-3D 1
View Cultured Cells University of Pittsburgh Drug Discovery Institute Multiple Cell Culture Flask Static-2D 0 A catch-all model to describe treatments applied to an entire cell culture flask. The cell line cultured in this model will change on a study-by-study basis, as this a generic model used to facilitate data entry of toxicity data.
View Davidson Organoid University of Pittsburgh Hukriede Lab Kidney 6 Well Plate [Generic] Static-3D 2
View demo University of Pittsburgh Drug Discovery Institute Liver Cross Flow Membrane Chip Fluidic-3D 1 4 cell liver model using Cas9 gene editable iPSC hepatocytes and 3 NPC cell lines
View Demo CS University of Pittsburgh Drug Discovery Institute Demo Liver Cross Flow Membrane Chip Fluidic-3D 1 demo MPS liver model
View Demo-Organ University of Pittsburgh Drug Discovery Institute Demo Demo-Organ Demo-Device Fluidic-3D 3 Organ model appropriate for use in generating data used in demonstrations and training.
View Demo Plate Model University of Pittsburgh Drug Discovery Institute Demo Demo-Organ 96 Well Plate Clear Flat Bottom Static-2D 1 A plate based, 96-well model used to demo the plate features of the Biosystics-AP
View Dopamine Brain Static Javelin Biotech Brain 96 Well Plate Clear Flat Bottom Static-2D 1 companion 96-well static model for the Mimetas Dopamingeric Brain MPS
View Duke-Skeletal Muscle (uP) Duke University Truskey Lab Skeletal Muscle (Truskey) Skeletal Muscle 12-Well Plate Static-3D 0 Microplate contractile force model
View Emulate Liver Chip University of Pittsburgh Drug Discovery Institute Liver Emulate Fluidic-3D 1
View EpiAirway 3D MatTek Corporation Lung 6 Well Plate [Generic] Static-2D 0 MatTek’s EpiAirway System consists of normal, human-derived tracheal/bronchial epithelial cells (TBE) which have been cultured to form a multilayered, highly differentiated model which closely resembles the epithelial tissue of the respiratory tract. Histological cross-sections of both the in-vitro tissue and a normal human bronchiole reveal a pseudostratified epithelial structure. Transmission electron microscopy shows numerous microvilli and cilia on the apical surface of the cultures and confirm the presence of tight junctions. Transepithelial electrical resistance of the tissue is similar to in vivo tissue. Mucins are secreted at the apical surface. The EpiAirway cultures are grown on cell culture inserts at the air-liquid interface, allowing for gas phase exposure of volatile materials for airway inflammation and irritant studies. This convenient format also allows the facile measurement of transepithelial permeability for inhaled drug delivery studies. The tissues can also be used to investigate mechanisms of bacterial infection of the respiratory tract. These and other studies involving asthma, cytokine responses, or various airway disorders can be performed using the EpiAirway tissue.
View EpiDerm MatTek Corporation Skin MatTek 24-well Plate Static-3D 0 EpiDerm (MatTek Corporation, MA, USA) is a reconstructed model of human tissue composed of neonatal foreskin-derived keratinocytes. The keratinocytes are cultured on specially prepared permeable cell culture inserts (Millicell CM, Millipore Corp., Bedford, MA, USA) and achieve advanced levels of differentiation characteristic of the mature epidermis. They are organized in basal, spinous, granular and cornified layers with a high concentration of keratohyalin granules and desmosomes.
View EpiDermFT MatTek Corporation Skin MatTek 24-well Plate Static-3D 0 EpiDerm Full Thickness (MatTek Corporation, MA, USA; EpiDermFT) is a reconstructed model of human tissue composed of normal, human epidermal keratinocytes (NHEK) and normal, human dermal fibroblasts (NHFB) cultured to form a multilayered model of the human dermis and epidermis. The keratinocytes are cultured on specially prepared permeable cell culture inserts (Millicell CM, Millipore Corp., Bedford, MA, USA) and achieve advanced levels of differentiation characteristic of the mature epidermis. EpiDermFT consists of organized keratin 5 expressing basal cells, involucrin and keratin 10 expressing spinous and granular layers, and cornified epidermal layers analogous to those found in vivo. The dermal compartment is composed of a collagen matrix containing viable normal human dermal fibroblasts (NHDF). The epidermal and dermal layers are mitotically and metabolically active and exhibit in vivo-like morphological and growth characteristics which are uniform and highly reproducible. A well-developed basement membrane is present at the dermal/epidermal junction.
View FCDI iCell isogenic BBB kit Texas A&M Tissue Chip Validation Center Brain 24 Well Transwell Static-2D 1
View Feto-Maternal interface (FMi) model Texas A&M University Han lab - UT medical branch at Galveston Menon Lab Fetal Membrane model Fetal Membranes Feto-Maternal interface (FMi) Organ-on-Chip (FMi-OOC) Static-3D 1 FMi-OOC is a microfluidic organ-on-chip (OOC) device containing primary or immortalized cells (decidua, chorion, and amnion [mesenchyme and epithelium]) from the fete-maternal interface (FMi) and collagen matrix harvested from primary tissue. The FMi-OOC is composed of four concentric circular cell/collagen chambers designed to mimic the thickness and cell density of the FMi in vivo. Each layer is connected by arrays of microchannels filled with type IV collagen to recreate the basement membrane of the amniochorion.
View GBM-chemotactic-invasion chips Utah State University Huang Lab GBMCI Brain GBM2019 Fluidic-2D 1
View Glomerulus (Mimetas 3-lane) Texas A&M Tissue Chip Validation Center Kidney Mimetas 3-Lane Organoplate Fluidic-3D 2 This model is based on the Mimetas 3-lane organoplate. It contains podocytes and glomerular endothelial cells layered in the "glomerular" channel, as well as an empty, "vascular" channel on the other side of the gel. The gel lane is filled with collagen ECM.
View Glucagon Secretion TR-FRET Roper Laboratory (FSU) Pancreas Roper_perfusion_multi_islet Fluidic-3D 0
View Gut 2D culture on 96 well imaging plate Texas A&M Tissue Chip Validation Center Gut 96 Well Plate Clear Flat Bottom Static-2D 0
View Gut 96 well Transwell plate Texas A&M Tissue Chip Validation Center Gut Corning 96 well Transwell Static-3D 1 Gut epithelial monolayers grown on Corning 96 well Transwell plates
View Gut CNBIO TC12 Texas A&M Tissue Chip Validation Center Gut Costar 24-well Transwell Fluidic-3D 2 Gut epithelial monolayers grown on 6.5 mm Transwell inserts in CNBIO MPS TC12 plates with flow in the lower compartment
View Gut Mattek Epi-Intestinal Texas A&M Tissue Chip Validation Center Gut Mattek Epi-Intestinal Static-3D 2 The Mattek Epi-Intestinal model is based on human small intestinal cells (ileum) differentiated after being seeded onto permeable supports under air-liquid interface culture conditions. This commercial model has been well characterized and is available in different formats, including a “full thickness” model in which gut cells are grown on top of a smooth muscle epithelial layer, or a “partial thickness” model with just the gut epithelial cells.
View Gut Mimetas 3-lane organoplate Texas A&M Tissue Chip Validation Center Gut Mimetas 3-Lane Organoplate Fluidic-3D 2
View Gut Transwell 6.5mm Texas A&M Tissue Chip Validation Center Gut Costar 24-well Transwell Static-3D 2 Gut epithelial monolayers grown on 6.5 mm Transwell inserts
View Hepatocyte Suspension University of Pittsburgh Drug Discovery Institute Liver Eppendorf Tube 1.5 mL Fluidic-3D 0 Used for acute metabolism study in hepatocyte suspensions.
View Hopkins-Baylor Intestine Donowitz/Estes Lab Intestinal Enteroid/Gut Intestine Costar 24-well Transwell Fluidic-3D 0 In development
View Hukriede Lab Kidney Organoid University of Pittsburgh Hukriede Lab Kidney 6 Well Plate [Generic] Static-3D 1
View Hukriede Lab Vascularized Kidney Organoid University of Pittsburgh Hukriede Lab Kidney 6 Well Plate [Generic] Static-3D 0
View Human Brain University of Pittsburgh Drug Discovery Institute Brain In vivo In Vivo 0
View Human Engineered Cardiobundles Duke University Truskey Lab Heart 12-Well Plate Static-3D 0
View Human Engineered CPVT Myocardium Disease Biophysics Group Heart Muscular Thin Film (MTF) Static-3D 0
View Human (In Vivo) University of Pittsburgh Drug Discovery Institute Multiple Organs In vivo In Vivo 1 Human in vivo model for studies containing in vivo data
View iHeps_ChipShop University of Pittsburgh Drug Discovery Institute Liver ChipShop Fluidic 557 Fluidic-3D 0
View iHeps-iEndo-iHSC-LAMPS University of Pittsburgh Drug Discovery Institute Liver Nortis Par-V1 Fluidic-3D 0
View iHeps-iEndo-iHSC-THP-1-LAMPS University of Pittsburgh Drug Discovery Institute Liver Nortis Par-V1 Fluidic-3D 0
View iHeps_iHSC_iEndo_ChipShop University of Pittsburgh Drug Discovery Institute Liver ChipShop Fluidic 557 Fluidic-3D 0 ChipShop model with iHeps, iHSC and iEndo cells from Rodrigo/Lanuza in Alex's lab
View iHeps_iHSC_iEndo_THP-1_ChipShop University of Pittsburgh Drug Discovery Institute Liver ChipShop Fluidic 557 Fluidic-3D 0
View iHeps LAMPS University of Pittsburgh Drug Discovery Institute Liver Nortis Par-V1 Fluidic-3D 3 LAMPS model with iHeps from Rodrigo/Alex's lab
View i-Heps LAMPS single cell model University of Pittsburgh Drug Discovery Institute Liver Nortis Par-V1 Fluidic-3D 1 preliminary model with single cell type iHep seeding in nortis devices to determine initial characteristics of iHep cells
View Inducible Endothelial Cells University of Pittsburgh Hukriede Lab Endothelium 10 cm plate Static-2D 0
View Infant Kidney University of Pittsburgh Drug Discovery Institute Kidney In vivo In Vivo 3
View Intestinal Enteroid [Monolayer TW] Donowitz/Estes Lab Intestinal Enteroid/Gut Intestine Costar 24-well Transwell Fluidic-3D 1 Enteroid cysts (three-dimensional [3D] structures) are seeded onto permeable membrane supports and grown to confluency to generate monolayers (two-dimensional [2D] structures). The resulting monolayers allow for controllable access to both apical and basolateral surfaces of the intestinal epithelial cells.The monolayer format, as opposed to the classical Matrigel-embedded 3D cyst culture, allows manipulations both at the apical and basolateral cell surfaces in a compartmentalized manner, thereby broadening options for treatment and collection of specimens (i.e. cells and culture media). It also improves reproducibility in evaluation of outcomes by reducing the variation in cell number and the restricted lumen volume inherent in the cysts cultures.
View Intestinal Enteroid [TAMU Caco-2 96w] Texas A&M Tissue Chip Validation Center Intestinal Enteroid/Gut Intestine Nunc MicroWell 96-Well [High Flange] Static-2D 0 A simple model where Caco-2 cells are seeding into a 96-well plate format. This model is used for comparison with JHU's transwell enteroid model
View Intestinal Enteroid [TAMU Caco-2 TW] Texas A&M Tissue Chip Validation Center Intestinal Enteroid/Gut Intestine Costar 24-well Transwell Static-3D 0 Caco-2 cell mono-layer on a 24-well transwell plate. This model is used for comparison with JHU's ranswell Enteroid model.
View Intestinal Enteroid [TAMU J2 96w] Texas A&M Tissue Chip Validation Center Intestinal Enteroid/Gut Intestine Nunc MicroWell 96-Well [High Flange] Static-2D 0 A simple model where primary J2 intestinal cells are seeding into a 96-well plate format. This model is used for comparison with JHU's transwell enteroid model
View iPSC-24 well University of Pittsburgh Drug Discovery Institute Liver 24 Well Plate Static-2D 0
View iPSC-96 well plate University of Pittsburgh Drug Discovery Institute Liver 96 well Plate Static-2D 0
View iPSC derived cardiomyocyte tissues Disease Biophysics Group Heart Fiber infused gel substrate Static-2D 0
View Kidney Proximal Tubule 2.0 [dual-channel chip] University of Washington Kidney Research Institute Kidney Nortis Dual-channel Chip Fluidic-3D 1
View Kidney Proximal Tubule [24-well static] University of Washington (Himmelfarb) Kidney 24 Well Plate Static-2D 0
View Kidney Proximal Tubule [384-well Static] Texas A&M Tissue Chip Validation Center Kidney PT (UW) Kidney 384 Well Plate Optilux Black/Clear Flat Bottom Static-2D 1 A 2D version of Himmelfarb's KPT model. Seeded with 1,000 cells per well in a black/clear-bottom 384-well plate.
View Kidney Proximal Tubule [96-well Static] Translational Center of Tissue Chip Technologies Kidney PT (UW) Kidney 96 Well Plate Clear Flat Bottom Static-2D 0 A "2D," 96-well plate based model of Himmelfarb et al.'s Kidney Proximal Tubule organ model. This model simply seeds the RPTEC directly into the wells of the plate. There is no flow.
View Kidney Proximal Tubule [Fluidic] University of Washington Kidney Research Institute Kidney PT (UW) Kidney Nortis Single Chamber Fluidic-3D 1 The kidney tubule MPS exhibits long-term viability, retains polarized expression and function of proteins essential for reabsorptive and secretory transport, responds to physiological stimuli, and performs critical biochemical synthetic activities. PTECs grown in the MPS polarize with proteins selectively localized to the basolateral and apical aspects of the tubular epithelium and exhibit expected morphological and functional phenotypes of proximal tubule epithelium in vivo out to 28+ days.
View Kidney Proximal Tubule [MIT, Triple Channel] Translational Center of Tissue Chip Technologies Kidney PT (UW) Kidney Nortis Triple Chamber Fluidic-3D 0 MIT's modification of the Kidney Proximal Tubule model to work in the triple channel Nortis Har-v1 (TSC-xxx) device instead of the original Nortis Par (SCC-xxx) device.
View Kidney Proximal Tubule [No Cells] Texas A&M Tissue Chip Validation Center Kidney PT (UW) Kidney Nortis Single Chamber Fluidic-3D 0 A cell-free version of Himmelfarb's KPT MPS model. It was created by Texas A&M to test compound binding to the device.
View Kidney Proximal Tubule [transwell static] Javelin Biotech Kidney Costar 24-well Transwell Static-2D 0
View Kidney Proximal Tubule [Weber et al. 2016] University of Washington Kidney Research Institute Kidney PT (UW) Kidney Nortis Par-V1 Fluidic-3D 0 An initial version of the KPT MPS model, based on Nortis' prototype Par-V1 device. This model was used in the Weber et al. 2016 The kidney tubule MPS exhibits long-term viability, retains polarized expression and function of proteins essential for reabsorptive and secretory transport, responds to physiological stimuli, and performs critical biochemical synthetic activities. PTECs grown in the MPS polarize with proteins selectively localized to the basolateral and apical aspects of the tubular epithelium and exhibit expected morphological and functional phenotypes of proximal tubule epithelium in vivo out to 28+ days.
View KOALA University of Wisconsin-Madison - Beebe Lab Kit on a Lid Assay Blood KOALA-PDMS Fluidic-2D 1 A passive pumping microfluidic chip with up to sixty parallel channels molded with PDMS placed on a plastic/ glass substrate for capture and analysis of immune cells from blood using bright field/ fluorescent microscope imaging.
View LAMPS University of Pittsburgh Drug Discovery Institute Liver (UPDDI) Liver Nortis Single Chamber Fluidic-3D 2 The Liver Acinus MicroPhysiology System (LAMPS) is a new generation of the liver model developed from SQL-SAL 1.5. The model includes 4-Liver cell types model and the Space of Disse
View LAMPS [Cell Free] University of Pittsburgh Drug Discovery Institute Liver Nortis Single Chamber Fluidic-3D 0 A cell free version of the LAMPS model used to investigate compound binding.
View LAMPS MCF7 Metastatic Breast Cancer Model University of Pittsburgh Drug Discovery Institute Liver Nortis Single Chamber Fluidic-3D 1 This model is the Nortis Device equivalent to the 96 MCF7 Metastatic Breast Cancer Co-Culture Model. It contains the 4-cell types from the LAMPS model with the addition of the varioius MCF7 mutant cells
View LAMPS MCF7 Metastatic Breast Cancer Plate Model University of Pittsburgh Drug Discovery Institute Liver 96 Well Plate Static-3D 1 In order to verify growth patterns in the LAMPS microfludic model with the addition of MCF7 breast cancer mutant cells a static plate co-culture model consisting of the 4 cell types of the liver and the addition of the MCF7 mutant cells was created.
View Lena Biosciences Liver Lena Biosciences Liver 48 well PerfusionPal Plate Fluidic-3D 1 Remarkable advances in three-dimensional (3D) cell cultures and organ-on-a-chip technologies have opened the door to recapitulate complex aspects of human physiology, pathology, and drug responses in vitro. The challenges regarding oxygen delivery, throughput, assay multiplexing, and experimental complexity are addressed to ensure that perfused 3D cell culture organ-on-a-chip models become a routine research tool adopted by academic and industrial stakeholders. To move the field forward, we present a throughput-scalable organ-on-a-chip insert system that requires a single tube to operate 48 statistically independent 3D cell culture organ models. Then, we introduce in-well perfusion to circumvent the loss of cell signaling and drug metabolites in otherwise one-way flow of perfusate. Further, to augment the relevancy of 3D cell culture models in vitro, we tackle the problem of oxygen transport by blood using, for the first time, a breathable hemoglobin analog to improve delivery of respiratory gases to cells, because in vivo approximately 98% of oxygen delivery to cells takes place via reversible binding to hemoglobin. Next, we show that improved oxygenation shifts cellular metabolic pathways toward oxidative phosphorylation that contributes to the maintenance of differentiated liver phenotypes in vitro. Lastly, we demonstrate that the activity of cytochrome P450 family of drug metabolizing enzymes is increased and prolonged in primary human hepatocytes cultured in 3D compared to two-dimensional (2D) cell culture gold standard with important ramifications for drug metabolism, drug-drug interactions and pharmacokinetic studies in vitro.
View Liver Sinusoid UC Berkeley Healy Lab Liver (Healy) Liver UCB Liver Sinusoid Device Fluidic-3D 1 A system to model the liver sinusoid
View Liver Sinusoid [TAMU 96w] Texas A&M Tissue Chip Validation Center Liver (Healy) Liver 96 Well Flat Clear Bottom Black Polystyrene TC-Treated Static-2D 1 A static, 2D companion model to UC-Berkeley's Liver Sinusoid MPS. Hepatocytes seeded into a 96-well plate at 100,000 cells per well.
View Liver Spheroid Javelin Biotech Liver 96-Well U-Bottom Plate Static-2D 0 Liver Cell Aggregates in u-bottom plates
View Liver vs CNBIO MPS (LC12) Plate CNBio Liver 96 Well Plate Clear Flat Bottom Static-2D 1 2D 96-well sandwich culture
View Liver vs Mimetas 2-lane 2D Mimetas Liver 384-Well Clear Flat Bottom Microplates TC-Treated White Polystyrene Static-2D 0
View Lumenex Large Port device University of Wisconsin-Madison - Beebe Lab Bone Marrow LumeNEXT Fluidic-3D 1 LumeNEXT uses two components - a microfluidic chamber and a removable PDMS rod. The microfluidic chamber is full with collagen that contain different mixes of cells. After collagen polimarization, the rod is removed and endothelial cells can be seed there. This device has a modification in one of the lateral ports. This port is bigger and enable the seed of spheroids. In the large port LumeNEXT device, the stroma and the tumor can be split and analyze independently but maintain the crosstalk.
View MANZ2-2 Davidson Organoid University of Pittsburgh Hukriede Lab Kidney 6 Well Plate [Generic] Static-3D 0
View MANZ-4-37 Davidson Organoid University of Pittsburgh Hukriede Lab Kidney 6 Well Plate [Generic] Static-3D 0
View MCF7 Metastatic Breast Cancer Monoculture Model University of Pittsburgh Drug Discovery Institute Liver 96 Well Plate Static-2D 0 Single MCF7 Mutant in a plate
View melanoma co-culture model University of Pittsburgh Drug Discovery Institute Liver 96 Well Plate Static-3D 1 4 cell liver model with addition of melanoma cells primary hepatocytes, LSEC, THP-1, LX-2 liver cells metastasis of melanoma cells
View mhToC V1 UofR Center for Musculoskeletal Research Multiple Modular human Tendon on Chip Static-3D 1
View microBrain 3D Javelin Biotech Brain 96-Well U-Bottom Plate Static-3D 0 iPSC-derived cortical neuron and astrocyte co-cultured spheroids. 50/50 neuron to astrocyte ratio, 20/80 GABAergic/Gluamatergic neuron type ratio.
View MicroDuo system for merged wells University of Wisconsin-Madison - Beebe Lab Multiple 192-well microDUO Fluidic-2D 1 384-well MicroDuo device where cells are under co-culture and bridged wells are analyzed together.
View microDUO system for single well analysis University of Wisconsin-Madison - Beebe Lab Multiple 384-wells microDUO Fluidic-2D 1
View microfluidic chips Zhang Lab (BWH & HMS) Multiple Organs microfluidic chips version 1 Fluidic-3D 0
View microHeart Javelin Biotech Heart 96-half-well plate (micro-patterned) Static-2D 0 iPSC-derived cardiomyocytes plated on a micropatterned 96-half-well plate. Micropatterning aligns cells similarly to structure of heart muscle in-vivo.
View microJoint University of Pittsburgh Lin Lab Joint microJoint Fluidic-3D 1
View Mimetas 2-lane Liver Chip Texas A&M Tissue Chip Validation Center Liver OrganoPlate® 2-lane 96 Fluidic-3D 0 iCell hepatocytes are seeded into collagen I gel (4mg/mL) at a density of 15,000 cells/uL in the gel channel. HMEC-1 (20,000 cells/uL) and THP-1 (3,000 cells/uL) are pooled and seeded into the fluidic channel. The device is placed on a rocker for gravity-driven perfusion and media is exchanged every 24h.
View Mimetas 3-lane Organoplate Mimetas Multiple Organs Mimetas 3-Lane Organoplate Fluidic-3D 0
View Mimetas Dopaminergic Brain MPS Javelin Biotech Brain Mimetas Organoplate 400 Static-3D 1 The OrganoPlate® 2-lane is an advanced microfluidic tissue culture device that contains 96 independent microfluidic chips. Each chip supports an ExtraCellular Matrix (ECM) channel and a perfused medium lane, with no physical barrier in between. A single chip is connected to four wells of the OrganoPlate®: a gel inlet, two medium reservoirs and an observation window. Any number of chips can be used in an experiment. For central nerve system culture without astrocytes no induced perfusion in the system is required.
View Mimetas liver University of Pittsburgh Drug Discovery Institute Liver (Mimetas) Liver Mimetas OrganoPlate Fluidic-3D 1 4-cell Liver acinus model in Mimetas 96 well organoplate for HTS
View Mimetas Liver 2.0 University of Pittsburgh Drug Discovery Institute Liver (Mimetas) Liver Mimetas Organoplate 400 Fluidic-3D 0 The UPDDI 4-cell liver in the 96 well microfluidic Organoplate for HTS
View Mimetas organoplate 400 University of Pittsburgh Drug Discovery Institute Liver Mimetas Organoplate 400 Fluidic-3D 1
View Moore Lab Microphysiological Peripheral Nerve Tulane University - Moore Lab Peripheral nervous system Moore Lab Dual Hydrogel Culture System Static-3D 4
View Mouse (In Vivo) University of Pittsburgh Drug Discovery Institute Multiple In vivo In Vivo 2 Mouse in vivo model for studies containing in vivo data
View Mouse TBI model University of Pittsburgh Drug Discovery Institute Brain Mouse In Vivo 0
View Muscle activation in geometrically insulated cardiac tissues node Wyss Institute-Kit Parker Lab Heart Cardiac tissue chip Static-2D 0 In cardiomyocytes, pacemaking arises from an interplay between hyperpolarizing and dominating depolarizing currents during the phase 4 depolarization period (the period between repolarization and the rising phase of the subsequent action potential). In the sinoatrial node, the hyperpolarization-induced inward current (HCN isoforms) of cardiac pacemaker cells plays a major role in pacemaking (47). However, in the case of our G-node where stem cell-derived CMs and NRVMs supposedly lack the expression of HCNs, the pacemaking potentials are a result of inward currents produced by Ca2+ cycling (driven by rhythmic releases of intracellular Ca2+ from the sarco/endoplasmic reticulum). The remaining question was how a region of cells initiate coordinated pacemaking and how this relates to electrical cell-to-cell coupling. The geometrical node design plays a crucial role here because the current being exchanged between individual cells of different membrane potentials is locally accumulated in the membrane capacitance at the edges and is reflected at the tissue edges. The reflection of intracellular currents at the tissue edges synchronizes the spontaneous activity in the structurally isolated small tissues like a G-node and increases their firing rate. The mechanism of reflection at the corners of cultures behave similarly (since downstream impedance is reduced), in particular the anterior corners with acute angles albeit less than in the G-node, and as a result, firing is enhanced in the whole anterior side.
View Muscular Thin Film (MTF) Wyss Institute-Kit Parker Lab Heart Muscular Thin Film Static-3D 0
View Neuro HTS Ananda Devices Brain NeuroHTSTM microplate Static-3D 1
View NMJ BioMEMS system Hesperos NCATS Data Group Peripheral nervous system NMJ BioMEMS system Fluidic-2D 0
View Nortis Single Cell Type Microfluidic University of Pittsburgh Drug Discovery Institute Liver Nortis Single Chamber Fluidic-2D 1
View -Not Specified- University of Pittsburgh Drug Discovery Institute -Not Specified- Multiple Organs Demo-Device Fluidic-3D 0 This is a contrived Model for legacy data and instances where a Model may not be suitable.
View NVU V1 Vanderbilt Institute for Integrative Biosystems Research and Education NVU / BBB (Vandy) Brain NVU Fluidic-3D 3
View Osteochondral Bioreactor System Four in Series University of Pittsburgh Center for Cellular and Molecular Engineering Joint (Lin) Bone Fabricated Osteochondral Construct 4 in Series Fluidic-3D 1 Four multi-layer devices in series. More information to be added later.
View Osteochondral Bioreactor System in 24 Well Plate University of Pittsburgh Center for Cellular and Molecular Engineering Joint (Lin) Bone 24 Well Fabricated Osteochondral Construct Fluidic-3D 1 The 3D structures of the bioreactor were modeled using Magics 14 (Materialise, Belgium). The chamber and insert were fabricated using a stereolithography apparatus (EnvisionTec, Germany) employing e-shell 300 as the resin. A multichamber bioreactor was fabricated and fitted into a microfluidic base. An individual bioreactor is composed of a removable insert within a chamber of a well on a 24-well microfluidic plate. The chamber is fixed in place with two O-rings. The osteochondral construct within the insert creates the separation between the upper (chondrogenic) and lower (osteogenic) medium conduits. Opposing gradients of chondrogenic and osteogenic factors and stimulants aid in forming an interface. A single bioreactor is formed by the inset and lid in a well of the plate. Chondrogenic medium (CM) are supplied through upper conduit and osteogenic medium (OM) through the lower conduit.
View Osteochondral model-3D University of Pittsburgh Center for Cellular and Molecular Engineering Osteochondral model-F2-2019 Bone Marrow 6 Well Plate [Generic] Static-3D 0
View Osteochondral tissue University of Pittsburgh Center for Cellular and Molecular Engineering Joint Osteochondral tissue chip Fluidic-3D 0
View Ovary Culture Northwestern Kim Lab Ovaries Lattice 8UP Fluidic-3D 1
View PANIS UPitt-Banerjee Pancreas Micronit OOC 3um porous 9um-membrane 8x16mm oval Fluidic-3D 0 PANIS: Human Pancreatic Islet MPS It is a glass based MPS based on Micronit microfluidic device
View Pitt-MGH Liver Acinus UPitt-MGH Liver (Pitt-MGH) Liver Liver Acinus Device v1.1 Fluidic-3D 0 PDMS casting with multiple channels lined with hepatocytes, and NPCs
View Polycystic Ovarian Culture Northwestern Kim Lab Ovaries Lattice 8UP Fluidic-3D 1
View Private Model Nortis-Demo Demo-Organ Private device Fluidic-3D 1
View Private Plate Model Nortis-Demo Multiple Horizontal 8 Well Fluidic-2D 0
View Proximal Tubule (CNBio - T12) Texas A&M Tissue Chip Validation Center Kidney CNBio - T12 plate Fluidic-3D 1 This model uses the CNBio T12 plate with Transwells (0.4uM). Proximal tubule cells are seeded either in monoculture, or co-culture with endothelial cells, and exposed to flow within the system.
View Proximal Tubule (Transwell) Texas A&M Tissue Chip Validation Center Kidney 24 Well Transwell Static-3D 0 Proximal tubule cells are seeded in either a monoculture, or in a co-culture with endothelial cells on the membrane of the transwell.
View Proximal Tubule/Vascular (Mimetas 3-lane) Texas A&M Tissue Chip Validation Center Kidney Mimetas 3-Lane Organoplate Fluidic-3D 1 This chip is based on the Mimetas 3-Lane Organoplate. RPTECs are seeded in the "tubular" channel, and HUVECs in the "vascular" channel. 4mg/mL Collagen I gel separates the 2 fluidic layers.
View psensor for hToC V1 UofR Center for Musculoskeletal Research Tendon Flow-Enabled Photonic (PPhRR) Biosensor Fluidic-3D 1
View Rat (In-Vivo) University of Pittsburgh Drug Discovery Institute Multiple Organs In vivo In Vivo 2 Rat in vivo model for studies containing in vivo data
View Rat perfused kidney University of Pittsburgh Drug Discovery Institute Kidney In vivo In Vivo 0
View RED - Bone Texas A&M Tissue Chip Validation Center Bone (Columbia) Bone Single-Use RED Plate for 48 Samples Static-2D 0 This model represents the RED assay conditions and protocol used when testing serum compound binding for the media used in Columbia's Bone/Bone-Tumor model.Serum protein concentration is at ??%.
View RED - Intestinal Enteroid Texas A&M Tissue Chip Validation Center Intestine Single-Use RED Plate for 48 Samples Static-2D 3 This model represents the RED assay conditions and protocol used when testing serum compound binding for the media used in JHU's Intestinal Enteroid model.
View RED - Kidney Proximal Tubule Texas A&M Tissue Chip Validation Center Kidney PT (UW) Kidney Single-Use RED Plate for 48 Samples Static-2D 0 This model represents the RED assay conditions and protocol used when testing serum compound binding for the media used in the Kidney Proximal Tubule model.Serum protein concentration is low, at 0.5%.
View RED - Liver Sinusoid Texas A&M Tissue Chip Validation Center Liver (Healy) Liver Single-Use RED Plate for 48 Samples Static-2D 0 This model represents the RED assay conditions and protocols used when testing media serum compound binding for the media used in UCal Berkeley Liver Sinusoid model, as well as derived models from Texas A&M.
View RED - SQL-SAL 1.5 Texas A&M Tissue Chip Validation Center SQL-SAL 1.5 Liver Single-Use RED Plate for 48 Samples Static-2D 0 This model represents the RED assay conditions and protocols used when testing media serum compound binding for the media used in University of Pittsburgh SQL-SAL 1.5 model, as well as derived models from Texas A&M.
View Salivary Gland [URochester] University of Rochester Salivary Gland Tissue Chip Salivary Glands UR-MicroBubble Static-3D 0
View Single Lumen device for bone marrow microenvironment University of Wisconsin-Madison - Beebe Lab Bone Marrow LumeNEXT Fluidic-3D 0 Biomimetic model for bone microenvironment. We created a model where different bone marrow cells populations (Bone Marrow Mesenchymal Stem cells, adipocytes, osteoblast, fibroblast, osteoclast, and macrophages) are embedded within a 3D collagen matrix. A lumen structure lined with iPSCs endothelial cells represent blood vessels. The cell media is perfused through the lumen channel.
View Skeletal Muscle MPS E-stim University of Florida Malany Lab Skeletal Muscle PDMS chip with electrodes Fluidic-3D 0
View Skeletal Muscle MPS non-stim University of Florida Malany Lab Skeletal Muscle PDMS chip without electrodes Fluidic-3D 0
View Skeletal Myobundle Duke University Truskey Lab Skeletal Muscle (Truskey) Skeletal Muscle Myobundle Frame Static-3D 1 An MPS device for a contractile force model. Donor cells are split and expanded to prepare enough stock cultures to prepare myobundles. After 4-5 days of growth and expansion, the human skeletal muscle cells are mixed with non-growth factor reduced Matrigel™, thrombin, fibronectin and human growth media. The cell-containing mixture is placed into a mold that helps form the initial muscle bundles. The myobundles are kept in culture for 5-7 days and then the media is changed to differentiation media. The myobundles are kept in the differentiation medium for another 5-7 days. After differentiation the myobundles are tested for their responsiveness to electrical stimulation by developing a contraction.
View Skin MPS Columbia University Laboratory for Stem Cells and Tissue Engineering Skin (Columbia) Skin HeLiVaSkCa Skin Module Static-3D 1 The model consists of iPSC-derived keratinocytes form a multilayered epidermis and cornifiedlayer at the surface of the epidermis on a dermis consisting of iPSC-derived fibroblasts, similar to those from human keratinocytes and fibroblasts. Individual skin constructors are placed into the wells of a 48-well plate.
View Skin MPS [TW-12] Columbia University Laboratory for Stem Cells and Tissue Engineering Skin (Columbia) Skin Costar 12-well Transwell Fluidic-3D 0 MIT's static, 2D companion model for the Columbia Skin MPS
View Small Airway - ALI (UPenn) Texas A&M Tissue Chip Validation Center Lung Small Airway Chip (UPenn) Static-3D 0
View Small Airway - ALI (UPenn) - Open Design Texas A&M Tissue Chip Validation Center Lung Small Airway Chip (UPenn) Fluidic-3D 0 This is the same base chip as the earlier small airway model, however the top layer has been altered to allow for airflow directly over the cells seeded at ALI (See picture)
View SQL-SAL 1.0 University of Pittsburgh Drug Discovery Institute Liver (UPDDI) Liver Nortis Single chamber (v0.9) Fluidic-3D 1 Sequentially layered, self-assembly liver (SQL-SAL). This microfluidic model is a single chamber model with 4 liver cells types and three addition/sample locations associated to it (Influent, Chamber, and Effluent).
View SQL-SAL 1.0 CS Rhomb 24uL University of Pittsburgh Drug Discovery Institute Liver (UPDDI) Liver Rhombic Chamber Chip 24uL Fluidic-3D 0 ChipShop hard plastic device prototype
View SQL-SAL 1.5 University of Pittsburgh Drug Discovery Institute SQL-SAL 1.5 Liver Nortis Single Chamber Fluidic-3D 3 Modified SQL-SAL 1.0. This 4-liver cell microfluidic model has a single chamber model and has three addition/sample locations associated to it (Influent, Chamber, and Effluent).
View SQL-SAL [TAMU 96w] Texas A&M Tissue Chip Validation Center SQL-SAL 1.5 Liver 96 Well Plate Static-2D 1 TAMU static, 2D version of the SQL-SAL 1.5 Liver MPS model based on standard 96-well plate. The SQL-SQL 1.5 (3D) is a single chamber model and has three addition/sample locations associated to it (Influent, Chamber, and Effluent).
View Static vLAMPS University of Pittsburgh Drug Discovery Institute vLiver (UPDDI) Liver Micronit OOC small oval Static-3D 0 vLAMPS = Vascularized Human Liver Acinus Microphysiological System. It is a glass based MPS based on Micronit middle layer but kept under static culture on a 60mm petri dish
View Stone-BBB-3Cell-12Well Texas A&M Tissue Chip Validation Center Brain Costar 12-well Transwell Static-3D 2 This is a 3 cell model with human astroglial cells (ATCC CRL-8621) and human brain vascular pericytes (ScienCell #1200) cultured on the basolateral surface of a collagen pre-coated 12mm transwell and human brain microvascular endothelial cells (ScienCell #1000) on the apical surface. Standard Corning® 12mm PET transwells (catalog no. 3462) coated with rat tail collagen I by the user prior to use. Inserts with 3.0µm Pore Polyester (PET) Membrane, 12mm trans wells in 12 well plates.
View Stone-BBB-3Cell-24Well Texas A&M Tissue Chip Validation Center Brain 24 Well BioCoat-COL Transwell Static-3D 2 This is a 3 cell model with human astroglial cells (ATCC CRL-8621) and human brain vascular pericytes (ScienCell #1200) cultured on the basolateral surface of a collagen pre-coated 6.5mm transwell and human brain microvascular endothelial cells (ScienCell #1000) on the apical surface. Corning® BioCoat® Collagen I Inserts with 3.0µm Pore Polyester (PET) Membrane pre-coated with Collagen Type I extracellular matrix, 6.5mm trans wells in 24 well plates.
View Stone-BBB-3Cell-6Well Texas A&M Tissue Chip Validation Center Brain 6 Well BioCoat-COL Transwell Static-3D 2 This is a 3 cell model with human astroglial cells (ATCC CRL-8621) and human brain vascular pericytes (ScienCell #1200) cultured together on the same side of a collagen pre-coated 24mm transwell and human brain microvascular endothelial cells (ScienCell #1000) on the opposite surface of the membrane. Corning® BioCoat® Collagen I Inserts with 3.0µm Pore Polyester (PET) Membrane were purchased pre-coated with Collagen Type I extracellular matrix, 24mm trans wells in 6 well plates.
View Suspension Cells University of Pittsburgh Drug Discovery Institute Multiple IQue Flow Cell Fluidic-3D 1 Cells in suspension
View Takayama Kidney-on-a-Chip Takayama Lab Kidney Takayama Lab Kidney Device Fluidic-3D 1 Two channel kidney epithelial model with a porous polyester membrane
View TBI Stretch Model University of Pittsburgh Drug Discovery Institute Brain BioFlex Silastic plate Static-2D 1
View Tissue Engineered Blood Vessel - 2 Layer Duke University Truskey Lab TEBV Vasculature TEBV Chamber Fluidic-3D 1 The molds used in this work were created using acrylic and composed of 5 parts, which form the fabrication mold and prefusion chamber (Fig. S1). The TEBV (2 layers) fabrication mold is formed from parts A, B, and C. Part A housed the mandrels about which TEBVs were made and is used in both the fabrication mold and prefusion chamber. There are four steel hollow mandrels (outer diameter 0.63 mm, inner diameter 0.33 mm) at opposite sides of part A, which are mirror reflections of each other and link the assembled chamber to the perfusion tubing and pump. In the fabrication step, the halves of each mandrel are inserted into the chamber (Part A) and brought into contact with each other (Fig. S1ai and S1bi). Part B forms the top layer of the seeding mold with inlets/outlets and grooves, and part C is the bottom layer of the seeding mold with grooves (Suppl Fig. S1aii and S1bii). The grooves on the top and bottom layers each form four semicircular channels (diameter 2.2 mm, length 24 mm) to be used as molds. Once the high-density collagen containing the hNDFs is added and gelled, parts B and C are removed, and the collagen TEBVs are dehydrated. Then the mandrels are drawn out forming a lumen. Following fixation of the collagen tubing on the mandrels, two new flat covers are added (parts D and E) and the final perfusion chamber is completed. The steel mandrels are used for perfusion, with one side acting as the media inlet, and the other as the outlet.
View Tissue Engineered Skeletal Muscle Model Duke University Truskey Lab Skeletal Muscle 12-Well Plate Fluidic-3D 0
View Tissue Engineered Ventricle Disease Biophysics Group Heart Tissue Engineered Ventricle Static-3D 0
View TPF-11-743 monoculture University of Pittsburgh Drug Discovery Institute Skin 96 Well Plate Static-2D 0
View TPF-14-346 University of Pittsburgh Drug Discovery Institute Skin 96 Well Plate Static-2D 0
View TPF-16-238 monoculture University of Pittsburgh Drug Discovery Institute Skin 96 Well Plate Static-2D 0
View TPF-16-255 monoculture University of Pittsburgh Drug Discovery Institute Skin 96 Well Plate Static-2D 0
View TPF-18-347 University of Pittsburgh Drug Discovery Institute Skin 96 Well Plate Static-2D 0
View Transwell any cell type University of Pittsburgh Drug Discovery Institute Multiple Organs 24 Well Transwell Static-2D 0 General single cell (any cell type) in transwell
View Vascularized Tumor Model UC Irvine Christopher Hughes Lab Vasculature / Vascularized Tumor Vasculature UCIVTM Fluidic-3D 7 This “tumor-on-a-chip” platform incorporates human tumor and stromal cells that grow in a 3D extracellular matrix and that depend for survival on nutrient delivery through living, perfused microvessels.
View Vascularized Tumor Monoculture [96w] UC Irvine Christopher Hughes Lab Vasculature / Vascularized Tumor Vasculature 96 Well Plate Static-2D 3 A monoculture of various cancer cell lines used to provide companion growth data for cancer cell lines that are used in the parent, 3D Vascularized Tumor Model.
View Vascularized Tumor [TAMU 96w] Texas A&M Tissue Chip Validation Center Vasculature / Vascularized Tumor Vasculature 96 Well Flat Clear Bottom Black Polystyrene TC-Treated Static-2D 4 A 2D "companion model" in a 96-well plate made by TAMU
View Venous Reservoir University of Pittsburgh Drug Discovery Institute Venous Reservoir Vasculature Reservoir Fluidic-3D 0
View Vessel adventia Zhang Lab (BWH & HMS) Vasculature Whole thermoplastic chip-1 Fluidic-3D 2
View vLAMPS University of Pittsburgh Drug Discovery Institute vLiver (UPDDI) Liver Micronit OOC Fluidic-3D 4 vLAMPS = Vascularized Human Liver Acinus Microphysiological System. It is a glass based MPS based on Micronit microfluidic devices.
View vLAMPS PANIS coupling University of Pittsburgh Drug Discovery Institute Multiple Organs Micronit OOC two-organ (Biomimetic and organoid) series coupling Fluidic-3D 0 Coupling of the vLAMPS (vascularized Human Liver Acinus MPS) and the Pancreatic Islet MPS (PANIS) with a common medium. The connection is carried out through the secretome-rich hepatic chamber of the vLAMPS to the top-chamber of the PANIS. Media is collected from the PANIS bottom chamber and the vascular-chamber of the vLAMPS.
View vLAMPS small oval 0.45um porous 12um-membrane University of Pittsburgh Drug Discovery Institute vLiver (UPDDI) Liver Micronit OOC 0.45um porous 12um-membrane 7x14mm oval Fluidic-3D 1 vLAMPS = Vascularized Human Liver Acinus Microphysiological System. It is a glass based MPS based on Micronit microfluidic device
View vLAMPS small oval 3um porous 20um-membrane University of Pittsburgh Drug Discovery Institute vLiver (UPDDI) Liver Micronit OOC 3um porous 20um-membrane 7x14mm oval Fluidic-3D 0 vLAMPS = Vascularized Human Liver Acinus Microphysiological System. It is a glass based MPS based on Micronit microfluidic devices
View vLAMPS small oval 3um porous 9um-membrane University of Pittsburgh Drug Discovery Institute vLiver (UPDDI) Liver Micronit OOC 3um porous 9um-membrane 7x14mm oval Fluidic-3D 0 vLAMPS = Vascularized Human Liver Acinus Microphysiological System. It is a glass based MPS based on Micronit microfluidic device
View vs Mimetas 2-lane_2D Texas A&M Tissue Chip Validation Center Liver 384 Well Plate Optilux Black/Clear Flat Bottom Static-2D 1 Seeded iHeps with gel
View well based LAMPS University of Pittsburgh Drug Discovery Institute Liver 96 well Plate Fluidic-2D 1 2D LAMPS model using doxycycline induced SIRT1 knowndown iPSC hepatocytes
View Well based Lamps model University of Pittsburgh Drug Discovery Institute Liver 96 Well Plate Static-2D 1 2D well based LAMPs using CDI 2.0 iPSC-hepatocytes
View Well based LAMPS model University of Pittsburgh Drug Discovery Institute Liver 96 Well Plate Static-2D 1 LAMPS model using cryopreserved human hepatocytes
View Well Based vLAMPS Transwell University of Pittsburgh Drug Discovery Institute Liver 24 Well Transwell Static-3D 1
View White Adipose [TAMU 384w] Texas A&M Tissue Chip Validation Center White Adipose (Healy) Adipose 384-Well Clear Flat Bottom Microplates TC-Treated White Polystyrene Static-2D 2 A companion model for 2D to 3D comparison to University of California Berkley's White Adipose MPS
View White Adipose Tissue UC Berkeley Healy Lab White Adipose (Healy) Adipose WAT-Chip Fluidic-3D 2 The WAT MPS mimics the physiological environment of adipose tissue with three main elements: a media channel, circular cell chambers, and a microporous membrane in between. Analogous to the in vivo blood circulation, media travels through the media channel as a vasculature like microcirculation between multiple WAT chambers and constantly transports fresh nutrients and other soluble factors (e.g. drug compounds, cytokines) to and metabolic waste and secreted factors away from the tissue. The media channel and WAT chambers are connected via small micropores (diameter 3 μm) that act as a perfusion barrier. The perfusion barrier mimics the in vivo endothelial barrier by allowing nutrients, drugs, and other media compounds to diffuse to the tissue while protecting the cells from shear stresses. The circular geometry of the WAT chambers (diameter 600 μm, height 50 μm) creates a homogeneous supply with nutrients for the entire WAT tissue and enables the direct exchange of soluble factors with the media for each individual cell, which is important as in vivo each adipocyte is attached to at least one capillary.
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